Sinéad Weldon Selected Research

cathepsin S

1/2022	Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome.
1/2021	Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice.
5/2020	Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics.
1/2019	Targeting of cathepsin S reduces cystic fibrosis-like lung disease.
1/2019	Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function.
7/2014	miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production.

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Sinéad Weldon Research Topics

Disease

14	Inflammation (Inflammations) 01/2022 - 03/2010
13	Lung Diseases (Lung Disease) 01/2022 - 10/2011
12	Cystic Fibrosis (Mucoviscidosis) 05/2021 - 12/2009
9	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 08/2018
7	Pneumonia (Pneumonitis) 01/2022 - 07/2014
3	Infections 01/2022 - 10/2010
3	Acute Lung Injury 01/2022 - 04/2013
2	Obstructive Lung Diseases (Obstructive Lung Disease) 05/2021 - 01/2020
2	Bronchiectasis 05/2021 - 03/2010
1	COVID-19 01/2022
1	Disease Susceptibility (Diathesis) 01/2022
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022
1	Disease Progression 05/2021
1	Eosinophilia 01/2020
1	Multiple Sclerosis 01/2020
1	Virus Diseases (Viral Diseases) 01/2020
1	Asthma (Bronchial Asthma) 01/2020
1	Respiratory Hypersensitivity 01/2019
1	Pseudomonas Infections 07/2014
1	Periodontal Diseases (Periodontal Disease) 10/2010
1	Atherosclerosis 06/2004

Drug/Important Bio-Agent (IBA)

9	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 03/2010
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2010
6	cathepsin SIBA 01/2022 - 07/2014
5	Protease Inhibitors (Protease Inhibitor)IBA 01/2022 - 03/2010
5	CytokinesIBA 01/2022 - 10/2010
3	Cysteine Proteases (Cysteine Protease)IBA 01/2022 - 01/2019
3	Peptides (Polypeptides)IBA 01/2021 - 01/2019
3	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2021 - 12/2009
2	InterferonsIBA 01/2022 - 01/2022
2	Interleukin-8 (Interleukin 8)IBA 01/2022 - 10/2010
2	LipopolysaccharidesIBA 01/2017 - 10/2010
2	ElafinIBA 01/2015 - 04/2013
1	Antiviral Agents (Antivirals)IBA 01/2022
1	Interleukin-6 (Interleukin 6)IBA 01/2022
1	Chemokine CCL26IBA 01/2022
1	CathepsinsIBA 01/2022
1	SerpinsIBA 01/2022
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2022
1	Interleukin-10 (Interleukin 10)IBA 01/2022
1	Interleukin-13IBA 01/2022
1	Salivary CystatinsIBA 01/2022
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 09/2020
1	Pancreatic Elastase (Elastase)IBA 05/2020
1	AllergensIBA 01/2020
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2020
1	VenomsIBA 01/2019
1	CathelicidinsIBA 01/2019
1	MucinsIBA 01/2019
1	PAR-2 ReceptorIBA 01/2019
1	Chemotactic FactorsIBA 01/2019
1	SmokeIBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	ChemokinesIBA 01/2017
1	Serine Proteases (Serine Protease)IBA 01/2015
1	DefensinsIBA 07/2014
1	LactoferrinIBA 07/2014
1	Proteasome Endopeptidase Complex (Proteasome)IBA 04/2013
1	Recombinant ProteinsIBA 10/2011
1	Toll-Like Receptors (Toll-Like Receptor)IBA 10/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2010
1	Conjugated Linoleic AcidsIBA 06/2004
1	Fatty Acids (Saturated Fatty Acids)IBA 06/2004
1	CholesterolIBA 06/2004
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 06/2004

Therapy/Procedure

11	Therapeutics 01/2022 - 03/2010